Tef [Eragrostis tef (Zucc.) Trotter] is one of the major staple crops grown in North West Amhara National Regional State; however, its productivity is low due to an increase in soil acidity and poor soil fertility problems. Thus, soil amelioration wth integrated use of organic and inorganic fertilizers with lime on acid soils is vital to improve soil properties and crop yield. Field experiment was conducted to investigate the effects of integrated commercial lime, NPSB blended fertilizer and cattle manure on the yield of tef at Koga Irrigation Scheme, Mecha district, during the 2021 main rainy season. Factorial combination of two levels of lime (0 and 2.5 t ha -1 ), five levels of NPSB blended fertilizer (0, 50, 100, 150 and 200 kg ha -1 ) and two levels of cattle manure (0 and 5 t ha ) treatments were laid out in a randomized complete block design (RCBD) with three replcations. All data were collected timely following their standard methods and procedures. The collected crop data were subjected to analysis of variance using R software. Mean separation for significant treatments was done using LSD. The results showed that the interaction effects of lime, cattle manure and blended NPSB had significant effects on phenology, growth and yield parameters. Crop yield and yield components were increased with cattle manure, NPSB blended fertilizer and lime rates. The maximum straw yield (5949.02 kg ha ) was recorded by the application of 2.5 t ha -1 lime, 5 t ha -1 cattle manure and 200 kg ha NPSB blended fertilizer. The combined application of 2.5 t ha -1 lime, 5 t ha -1 cattle manure and 150 kg ha -1 NPSB blended fertilizer resulted in the highest grain yield (2580.78 kg ha ), biomass yield (8425.53 kg ha -1 ), panicle weight (2.4 g/p) and harvest index (30.63%). This combined also increased the grain yield of tef by 200.9 % and 37.8% when compared to the treatments with zero and the sole applications of recommended NPSB blended fertilizer (100 kg ha -1 ), respectively. The economic analysis revealed that the combined application of 2.5 t ha -1 lime, 150 kg ha -1 NPSB blended fertilizer and 5 t ha -1 cattle manure yielded a maximum net profit of 131383.3 ETB ha -1 with an acceptable marginal rate of return (676 %). The increase in most growth and yield related parameters raised together with the increase in application rate up to 150 kg ha -1 NPSB blended fertilizer, high rates of lime (2.5 t ha -1 ) and cattle manure (5 t ha -1 ) and decreased when NPSB blended fertilizer more than 150 kg ha -1 . This shows that application of lime and cattle manure more than the tested rates with NPSB blended fertilizer rate may be increased the yield of tef in the study area. Therefore, further experiment will be mandatory through raising the rates of lime and cattle manure more than the tested rates in the previous trial and repeate over years and across locations to establish the best recommendation. -1 -1 -1 -1