Bread wheat (Triticum aestivum L.) is one of the most economically important cereal crops cultivated in north west Ethiopia. However ,appropriate seeding and nitrogen fertilizer rate have been among the most limiting factors for wheat production in North-western Ethiopia. A field experiment was conducted to investigate the effect of different seeding rate and level of nitrogen fertilizer at Debre Tabor cereal research sub center during 2021/22 main cropping season. The treatment consisted of factorial combinations of four seeding rates (100, 150, 200 and 250 kg/ha) and five elemental nitrogen fertilizer levels (0, 50, 100, 150 and 200 kg /ha) in randomized complete block design with three replications. Data on yield and yield component parameters of bread wheat were collected. These data were subjected to SAS-9.4 software to compute the analysis of variance and correlation analysis. Results of the study revealed that most yield and yield component of wheat were significantly affected by the main and interaction effects of (seed and nitrogen fertilizer rates). Significantly higher plant height(1067cm), spike length(13.0cm), number of spikelet/spike (13), 1000 kernels weight(45gm), number of kernels/ spike(52), grain yield(6200Kg/ha), biological yield(10128Kg/ha) and harvest index(51.7) were recorded when wheat was planted at seeding rate of 200 kg/ha with 150 kg/ha nitrogen level. Similarly the partial budget analysis indicated that 200 kg ha -1 seed rate with 150 kg N ha -1 gave the highest net return (94947.90ETB) with acceptable marginal rate of return 3994%. Thus, based on the result of the study we can conclude that planting of wheat at 200kgha -1 of seed with150 kg of N ha is recommended for the farmers for increasing wheat production in the study area. However, to reach at conclusive recommendation the experiment should be repeated across different locations and years. -1