Head cabbage (Brassica oleracea L.) is an important vegetable crop in Ethiopia which may help to improve the economic status of poor farmers. It is used as a source of various nutrients and income for smallholder farmers. However, in the study area, the productivity of head cabbage remained low due to inappropriate use of nitrogen fertilizer rate and low yielding capacity cultivars also poor soil fertility status. Therefore, the present study was conducted with the purpose of evaluating the effects of nitrogen fertilizer and cabbage cultivar on the growth and yield of head cabbage cultivar. The study was conducted during the 2020/2021 irrigation season in Koga Irrigation Scheme, North Mech district. The treatments consisted of four levels of nitrogen fertilizer rate (0, 36.5, 73 and 109.5 t ha ) and three cultivars (Copenhagen market, Lendini and Tana), which were laid down in a randomized complete block design (RCBD) with three replications. Data collected on phenological, growth and yield related parameters were analyzed using SAS (Version 9.2) software. The results of the study showed that head cabbage cultivars and rate of nitrogen were significantly influenced days to 50% head initiation, days to 90% maturity, head height, head diameter, head weight, unfolded number of leaves, number of folded leaves, head size yield, marketable head yield and total head yield. Accordingly, the highest head height (30.17 cm), head diameter (20.68 cm), head weight (2.79 kg), marketable head yield (63.83 t ha ) and total head yield (64.87 t ha -1 ) were obtained from the treatment combination of 109.5 kg ha -1 nitrogen with Lendini cultivar. The highest marketable head yield (63.83 t ha ) was recorded from 109.5 kg ha -1 nitrogen with Lendini cultivar while the lowest marketable cabbage yield (11.95 t ha -1 ) was obtained from control where nitrogen was not applied with local cultivar Copenhagen market. The same treatment combination also obtained the highest net benefit (565,911.31 ETB ha -1 ) with acceptable marginal rate of return value of 6035.12%, which can be recommended for profitable production of cabbage in North Mecha District and areas with similar agroecology. As the results are limited to one season and location, it is also recommended to repeat the study in different location and seasons. -1 -1 -1