Rust (Puccinia allii R.) is the major problem in garlic production in most areas of north western Ethiopia.Thus this study was conducted during 2020 cropping season.(1)To assessthe prevalence, incidence and severity of garlic rust in Enebsie Sarmider and GonchaSisoEnesie. (2)Evaluate the appropriate rate and frequency of Tilt application to manage garlic rust .Out of the total 60 fields assessed garlic rust disease was observed in thirty-seven (61.6%) garlic farm fields. Relatively high mean incidence, severity, and prevalence of garlic rust was observed at Enebsie Sarmider district which was 51.333%, 25.267% and 69.987% respectively and 40% incidence, 13.4% severity and 53.33% prevalence were recorded at Goncha Siso Enesie district. A field sown in August and September showed (59%) and (39.5%) severity respectively and a field with high plant population (56%) had the highest severity in relation to their respective variable classes in the districts during the cropping season. Rain feed field experiment was conducted at Bête emider kebele of Enebsie Sarmider in 2020 cropping season. Treatments were arranged in factorial randomized complete block design with three replications .The combination of(0.65l,0.75l,1l)rates and (F1,F2,F3and F4) spraying frequency of Tilt fungicide and unsprayed treatments was evaluated. Analysis of variance revealed that a combination of rate and spraying frequencies of the fungicide significantly reduced disease with correspondingly increased bulb yield of garlic. The economic analysis confirmed that the highest net benefit (682432.5ETBha ) and marginal rate of return (10422.1%) was obtained from plots treated with 0.75L with three times spraying. Generally, 0.75L with three times spraying frequency of Tilt was effective in controlling garlic disease and get the highest cost-benefit advantage as compared with other treatments. It should be repeated in other location that has similar agro ecology before it is recommended for the management of garlic Ethiopia. -1