Sorghum is the fourth most widely produced cereal in Ethiopia. Despite its coverage and importance, the productivity remains low due to several constraints, notably the use of poor-quality seed, limited availability of improved seed, and low adoption of pre-sowing seed treatment technologies, which results poor field establishment, low stand uniformity, and ultimately low yield, particularly in the lowland areas of Gondar. To address these challenges, an experiment was conducted at Gondar City in the GARC seed laboratory, and the field experiment at Metema and West Armachiho districts in the 2023 main cropping season to evaluate the effects of priming and coating on seed germination and yield of sorghum. The treatments consisted of a factorial combination of four priming materials (control, Tap water, MLE, and cow urine) and four coating materials (Control, Thiram, Apron Star, and Dynamic). The laboratory and field experiments were laid out in a CRD and RCBD design with four and three replications, respectively. Data were analyzed using R software version 4.4.2. Combined ANOVA revealed significant (p < 0.05) interaction effects of priming and coating on germination %, speed of germination, shoot and root length, VI₁ and VI₂, head length, width and weight, dry biomass, Stover yield, grain yield, and HI. In contrast, seedling dry weight, days to emergence, heading and maturity, plant height, and TSW were significantly (p < 0.05) affected only by the main effects of priming and coating. The highest germination (94.25%) and grain yield (4,364.92 kg ha⁻¹) were obtained from seeds primed with MLE and coated with Apron Star, followed by MLE-primed seeds coated with Thiram. The PBA also indicated that seeds primed with MLE and coated with Apron Star had the highest NB (146,999.7 Birr ha -1 ) with an acceptable level of MRR (116,792.1%) as compared to other treatments. Therefore, treatment combinations of seeds primed by MLE with coated by Apron Star, as well as seeds primed by MLE with coated by Thiram, are recommended for sorghum growers in lowland areas of Gondar and other similar agro-ecologies. However, these results are from a single year; extending the study across multiple seasons would help account for seasonal variability and strengthen the final recommendation.