Hot pepper is one of the most important spice and vegetable crops cultivated by smallholder farmers in Amhara region, particularly in the North Mecha district. However, the yield of the crop is low due to several production constraints, with the limited availability of improved varieties and soil nutrient deficiencies being among the major challenges. Hence, this experiment was carried out during the 2023 irrigation season in North Mecha, at Koga irrigation scheme. The aim was to identify highyielding varieties along with determining the optimum amount of blended NPSB fertilizer. The treatments consisted of four levels of blended NPSB fertilizer (0, 192, 242, and 292 kg ha ) and four hot pepper varieties (Vigro, Amando, Serenade, and Marekofana) arranged in 4x4 factorial combination in a Randomized Complete Block Design (RCBD) with three replications. Data on growth, yield, and quality parameters of the crops were collected and analyzed by using Statistical Analysis Software (SAS) version 9.4. The results clearly showed that hot pepper growth, yield, and quality were significantly influenced by varieties and NPSB fertilizer applied. Key parameters such as plant height, number of branches, leaf area index, green pod weight, number of pods per plant, marketable, unmarketable, and total green pod yields were influenced by the main and interaction effect of varieties and NPSB fertilizer. While days to the first harvest and all quality parameters were influenced solely by the main effects of both factors. Notably, significantly the highest marketable green pod yields (17.99 and 17.88 t ha -1 ) were obtained from Vigro and Amando varieties treated with 242 kg ha -1 NPSB respectively. However, the lowest marketable yield (4.32 t ha -1 )) was recorded from Marekofana with control. Based on the partial budget analysis, variety Vigro coupled with 242 kg ha -1 NPSB gave the highest net benefit of 657,946.5 birr ha and a marginal rate of return of 8,958.76%. The second acceptable marginal rate of return (5222.5%) was observed from open pollinated Marekofana variety with 242 kg ha -1 NPSB. As a result, based on the result of this experiment, the treatment combination of Vigro with 242 kg ha -1 NPSB is recommended for resource-full and commercial farms while Marekofana with 242 kg ha -1 NPSB can be advised for resource-poor farmers in North Mecha District and other areas with similar agro-ecological conditions.