In Ethiopia, micro and small enterprises development is promoted as strategy for jobs creation, economic growth and transformation. TVET institutions provided industry extension services aimed to impact skills development and productivity. However, TVET had limits from lack of occupational standards to use as basis of needs assessment. This study aimed to develop occupational standards and curriculum by investigating subjects from among occupations in Bahir Dar City Administration. The study employed design methodology including three phases for problems and needs assessment, analysis, and design and validation. The design research identified Trees and Fruit plants Nursery Management by purposive sampling defining significance to economy and lack of TVET curriculum addressing the labor force. Occupational standard was established based on literature review, task analysis and verification, and in collaboration with skilled nursery farmer and occupational trainers, and informed 5 components, and knowledge, skills and resources requirements, The curriculum of Trees and Fruit plants Nursery Management was also designed including 5 modules—namely, (1) Establishing Nursery, (2) Raising seedlings (3) Vegetative plant propagation (4) Nursing/Tending Seedlings and (5) Nursery Business Development. The design specified program goals, structure, and criteria of enrollment, delivery and qualification. The curriculum was validated in line with occupational standard by panel of 5 including experts and TVET stakeholders. The research assigned recommendations for the program‘s implementation, accreditation and integration into the Ethiopian TVET system