Schistosomiasis is a snail-borne trematode infection of man, domestic animals and wild animals in different parts of tropical and subtropical countries. It is an economically important disease caused by several Schistosoma species and results in economic losses through mortality and morbidity. This cross-sectional study aimed to estimate the prevalence, identifying potential risk factors, Snail diversity and assessing the perception and awareness of farmers towards bovine Schistosomiasis. Multistage cluster sampling method was used for selecting all study subjects. Out of 384 fecal sample examinations, 63 were revealed positive for Schistosoma parasite making the overall prevalence of 16.4%. Data were entered and analyzed by Statistical Packages for Social Sciences (SPSS) Version 20 .There was a significant difference (p < 0.05) in the prevalence among age groups, with high prevalence in adult (18.4%) than young animals (11.9%). Statistically significant variation in schistosomiasis (p < 0.05) was also observed among the different body condition of cattle, with the highest prevalence in poor body condition (25%) followed by medium body condition (11.7%) and the least in good body condition (8.6%). Highest (19.8%) prevalence was recorded at Wad kebele followed by Yetsed (18.8%), Godber (16.7%) and Yemehal (10.4%). Based on the questionnaire survey, Schistosomiasis is the 5th most important parasitic disease in cattle production. The knowledge, attitude and practice regarding to the cause, means of transmission, clinical symptoms and prevention methods in the study area were inadequate. In conclusion, schistosomiasis is one of the major health concerns of livestock production with poor body conditions in Dembecha district. Therefore, control of schistosomiasis based on drug treatment, snail control and appropriate sanitation measures were recommended.