The study was carried out to assess small-scale chicken farm management practices, opportunities, constraints, profitability, and evaluate the performance and profitability in urban and peri-urban areas in and around Debre Berhan City from 2020-2021. A purposive sampling technique was employed to select a representative area. A total of 20 small-scale (15 urban and 5 peri-urban) chicken farm were considered. For this study 450, day-old chickens from urban and 200 day-old chickens from peri-urban areas were taken randomly to evaluate the performance and profitability of existing chicken breeds. Semi-structured questionnaires and field observation (monitoring) were the main data collection methods. The collected survey data was analyzed using SPSS software Version 23. The constraints affecting small-scale farm and opportunities were ranked using index calculation method. Monitoring data were analyzed with ANOVA using GLM procedure by SAS version 9.4. Gross margin analysis was used to calculate the profitability of the farm. The overall result showed that most small-scale producers reared 60% Sasso T44 breed chicken in the study area, and 40% of farms used Bovans Brown. The overall result revealed that about 90%, 100%, and 60% consider the number of chicken, chicken age, and need for ventilation during chicken housing construction. The overall result shows that the first rank constraint in small-scale farms was feed cost in both production systems. The result shows that 1st ranked was high-demand eggs in both production systems. On-farm monitoring results revealed a significant difference (p<0.05) between the interaction of breeds and production systems of producers on the growth performance of chicken at 4, 6, 10, 16, 18, 20, and 22 weeks of age. Daily body weight gain and total body weight gain of Sasso T44 11.20 ± 0.13g and 1726.42 ± 19.66g were significantly higher (p<0.05) than Bovans Brown 10.46 ± 0.10g and 1611.46 ± 15.54g breed, respectively. The overall mortality rate of chicks at starter, grower, and pullet were 5.52%, 2.93%, and 1.38%, respectively. The mean age at sexual maturity of Bovans Brown and Sasso T44 in the urban area was 19 ± 1.55, and 23 ± 3.10 weeks, respectively, whereas in the peri-urban area were 20 ± 3.10 and 24 ± 3.10 weeks, respectively. The overall egg production was 115.48 ± 3.61 eggs whereas the mean of egg production for Bovans Brown 119.5 ± 2.02 was higher than Sasso T44 100.66 ± 2.55 per hen per 45 weeks. Even if constraints faced egg-laying chicken was profitability than 45 days of chickens. Small-scale chicken enterprises in urban areas were more profitable than peri-urban areas. In conclusion, Bovans Brown breed was early sexually mature than Sasso T44 in the same husbandry practice. Improving the management system could be a better method to increase the chicken performance and profitability of small-scale chicken farms.