Tick and tick borne haemoparasites are the main challenge of livestock production and productivity in Ethiopia particularly in North West Ethiopia due to favorable climate condition. A cross-sectional study was conducted from December 2020 to July 2021 on ixodid tick infestation and tick borne haemoparasites of cattle in selected districts of Awi zone with the objectives of determining the prevalence of ixodid tick infestation and tick borne haemoparasites, identifying the existing ixodid tick species, assessing seasonal variation of ixodid ticks and investigating the major risk factors associated with tick infestation and haemoparasites. The districts were selected purposefully and multistage sampling was used to select kebeles and households. A total of 384 cattle from the two districts were randomly selected and examined for the presence of tick infestation and tick borne haemoparasites. Ticks were identified at species level by using morphological identification keys under a stereomicroscope. Thin blood smear examinations were done to assess the presence of tickborne haemoparasites. The overall prevalence of tick infestation and tick born haemoparasite were 45% and 3%, respectively. A total of five potential risk factors were investigated for their association with cattle tick infestation and tick born haemoparasites using logistic regression and chi- square test. Age, body condition, agro ecology, and season were found significantly (P<0.05) associated with the risk of cattle tick infestation. Among the risk factors tested, season and body condition were found significantly (P<0.05) associated with the risk of tick borne haemoparasite by chi-square test. A total of seven tick species were identified. Of which, Amblyomma varigatum and Boophilus decoloratus were the predominant tick species encountered with prevalence of 55% and 15.7% respectively.However, in highland R. praetextatus species was not recorded. Furthermore, a total of 128 blood samples of cattle from Jawi district were examined using thin blood smear and 3% of them were infected by the Babesia bigemina. Tick infestation and tick born haemoparasite found in this study was high and seems to play vital role causes reduction of productivity, hide value and foreign exchange of the country and transmission of tick borne haemoparasites. Therefore, implementing the effective control and prevention methods is needed to mitigate risk factors for tick infestation and tick born haemoparasite in the study area.