Natural fish bones, that are known to have unique adsorption capacity, have been used in the present work for removal of heavy metals, copper, and lead, from wastewater. The effects of solution pH, adsorbent dose, initial heavy metal concentration, temperature and contact time on the adsorption process with respect to lead (II) and copper (II) removal were investigated via batch techniques. The results obtained from the experimental work showed that fish bone can be transformed into adsorbent for removing metal ions from the contaminated water solution. The results revealed that 98.03% and 78.9% of lead (II) and copper (II) respectively were at pH=6, adsorbent dose = 0.4 g, initial concentration =60ppm and reaction time= 12 hours. The adsorption behavior could be described well by the pseudo-second-order model. The adsorption isotherms were well fitted by Langmuir mode for both metal ions, suggesting the monolayer adsorption for Cu (II) or Pb (II). The adsorption process is spontaneous, favorable, endothermic and random, indicated by the thermodynamic equilibrium. With the use of a Scanning Electron Microscope (SEM), a large amount of Cu (II) and Pb (II) were seen as adsorbed on the surface of FB. The results showed the possibility of utilizing natural wastes as low- cost and effective alternative absorbents to remove Cu (II) or Pb (II) from aqueous solutions. Fish bones showed promising results in removing copper (II) and lead (II) from aqueous solution, thus this material could be used as low cost adsorbent to replace the expensive commercial activated carbon during adsorption process