The purpose of this study was to examine the effect of social marketing mix on water hyacinth prevention around Lake Tana shore. To address the research objective 145 sampled respondents were selected. Out of which 140 samples was analyzed. Purposive and convenience sampling methods were used. Questioners were distributed to conveniently selected respondents and the data gathered were analyzed based on these 140 samples using SPSS 20 software package. Descriptive statistics and explanatory research design were employed. All out puts were reported using percentage, mean, standard deviation, correlation analysis and regression result. The result indicates that Water hyacinth prevention strategies should focus on the social marketing mixes to solve the weed infestation problem bearing in mind from the context of the social marketing point of view. Among different social marketing mixes product proposition specifically human labor is advisable to remove that invasive weed from Lake Tana shore. As the research pointed out government commitment is also irreplaceable in the removal process so that it can support the activity through budget allotment and over all control. On the other hand to enable people to participate in the process, it needs public forum platform to make concerned bodies recognize the situation about over all weed characteristics and clearing methods as well as how to cooperate and share responsibilities. The result also shows that the requirement of motivational mechanisms to let people, mainly residents who are exposed to the infested area, to participate in the weed clearing activities and point out the need to study cost effective incentive mechanisms for those unique role play actors. In addition there should be made further study on the type and employment of machineries to remove water hyacinth from Lake Tana shore.