Rice is currently considered as a strategic food security crop in Ethiopia and it is considered as “millennium crop” expected to contribute to ensuring food security in the country. However, its yield is very low due lack of appropriate agronomic practices for various rice varieties, A filed experiment was carried out during 2021/2022 main cropping season at Fogera National Rice Research Center with the objective of examining the response of low land rice varieties to interrow spacing under rain-fed condition in fogera plain. The experiment was laid out in Randomized Complete Block Design (RCBD) in a factorial combination of four inter-row spacing (15cm, 20cm, 25cm and 30cm) and four low land rice varieties (Wanzaye, Shaga, Rib and X-Jigna) with three replication. The data on phenological, growth and yield parameters of rice were collected and analyzed using SAS-JMP-16 software. The result of the study revealed that most of the phenological, growth, yield and yield components of rice were significantly influenced by the main effect of inter-row spacing, variety, and their interaction effect. Planting of variety Shaga with an inter-row spacing of 25cm gave the maximum grain yield (7.33t ha ), panicle length (20.00cm), filled grain per panicle (134.86), above ground dry biomass (12t ha 1 ),thousand grain weight (35.10gm), and straw yield (4.66t ha VIII -1 ),The same treatment also gave the highest net benefit (261554.5 Birr ha -1 ) with the marginal rate of return (118621) followed by planting variety X-Jigna in an inter-row spacing of 25cm (NB =253086.5 Birr ha and MRR= 67117). Thus, it can be concluded that planting variety Shaga in an inter-row spacing of 25cm boost the productivity and profitability of low land rice e production under rain-fed condition in the study area and similar agro-ecologies. However, continuous research on agronomic practices needs to be conducted, since various rice varieties have been released both in the study area and in the country.