Land degradation has become an important global concern because of its adverse impactonfood security and the environment.This study was conducted to effect of land use types on selected soil physiochemical properties and soil organic carbon stockat Kesa Chewsa Kebele, in the northwest highlands of Ethiopia. Field experiment was conducted under three land use types namely cultivated land use, Acacia decurrens plantation land use, and eucalyptus plantation land use with three replications.Eighteen soil samples about 1kg were taken from the experimental land use type integrated withtwo depths(0-20cm) and (20-40cm).The collected data were subjected to two-way ANOVA analysis. The result showed that the investigated soil physio-chemical properties were influenced by land use types. The highest value of SOCS, OC, TN, OM, AvP were recorded in the acacia plantation land use, and the highest value of BD, soil pH, were recorded under cultivated land use. OC, TN, OM, AvP were higher fromsurfaceof the soil (0-20 cm). Soil pH, BD, SMC were higher under sublayer of the soil (20-40 cm).In order to improve the soil conditions and advance sustainable land use and agricultural productivity, there is a need to expand acacia decurrens plantation in similar Agro ecology.