Poor personal and environmental hygiene significantly contributes to food contamination and resultant food born disease. It is assumed that by their nature, street food contamination is unavoidable, yet millions of people depend on this source of nutrition and economic livelihood. This study was conducted to assess the knowledge, attitude and practice of street food vendors with regard to food safety and hygiene administrations. A cross-sectional descriptive study was conducted among 384 street food vendors working in Yeka and Addis Ketema Sub Cities, Addis Ababa, Ethiopia. Data were collected through face-to-face-interview, and observation methods using interviewer-administered questionnaire and an observational checklist respectively. Data was analyzed using SPSS v 25. Frequency and percentile were used to summarize the data and determine the degree of KAP. To test the relationship between knowledge, attitude and practice, person correlation coefficient was employed. The study found that only 20% of the street food vendors participated in the study have received a food safety training while the majority (80%) haven’t ever received any kind of training. The degree of knowledge, attitude and practice was found to be 67.5%, 68.3% and 75.4% respectively. A significant strong positive relationship between food safety knowledge and practice, r ([384]) = [.63], p = [< .001] and a moderate positive relationship between attitude towards food safety and practice, r ([384]) = [.331], p = [< .001] were found. This study showed that (above 50%) of the street food vendors have good knowledge regarding food safety, and their attitudes towards food safety can be regarded as favourable (positive). Similarly, the food handling practices that was assessed during the study period showed that the majority of the street food vendors have good practices. Nevertheless, considerable number of respondents argued that the food handling practices were not sufficiently made safe and hygienic practices were very important. In addition, the result of this study confirmed that most of the street vending businesses were not clean and well equipped. Therefore, an effective and ongoing training and inspection on food safety practices should be given to all the street food vendors. Key words: Knowledge, attitude, knowledge, street, food safety, food vendors, Addis Ketema, Yeka, Ethiopia