Food borne diseases are preventable, if food protection principles are followed from primary production to the level of consumer. Ethiopia is not exceptional since the prevailing of poor food handling and sanitation practices, inadequate food safety laws, weak regulatory systems, lack of financial resources to invest on food safety, and lack of education and training for food handlers. The aim of study was to assess food safety of knowledge, attitude, and practice among meat handlers in abattoir and retail shops in case of Yeka and Bole sub-city. A cross-sectional survey was carried out among 244 meat handlers by using structured questionnaire to determine the food safety knowledge, attitude, and practices in an abattoir and retail meat shops of Yeka and Bola sub-city Addis Ababa Ethiopia. Chi square (χ2) test was also used to find the relationship between the sociodemographic characteristics with knowledge, attitude, and practice scores. P-value less than 0.05 were considered statistically significant. A cross-sectional survey was carried out among 244 meat handlers by using structured questionnaire to determine the food safety knowledge, attitude and practices in abattoir and retail meat shops of Yeka and Bola sub-city. The participants were 98% males; 52.2% between 20-30 years old and 30.3% were between the age of 32-40 years. Most of respondents were primary and secondary education levels (42.2%, 41%) respectively. About 51.2 % of respondents have unsatisfactory knowledge level with the mean score of 14.22 ± 3.069, which is below the cut of point 15 (≥ 68%). Around 95.9 % of respondents have good attitude about food safety with the mean of total score 16.36 ± 1.868. It was found that (96.3%) respondents had poor food safety practices with the mean total score of 11 ± 1.606. Chi square (χ2) analysis testing for the association between knowledge, attitude and practices with socio-demographic parameters indicate there was significant association between age and food safety practice, and practice with employment status P<0.05. Also, there is significant association level of education, field of duty, income with attitude.