Ethiopia is one of the developing countries in which agriculture is the primary source of its economy. Being dependent mainly on rainfall, this sector has been adversely affected by climate change and variability.The main objective of this study was to investigate the impact of climate change and variability on major crops and adaptation strategies in Minjar Shenkora District. Primary and secondary data were collected for the study. Primary data were collected from household questionnaires, key informant interview (KII) and focus group discussion (FGD); whereas, secondary data were collected from the major crop data collected from 2000-2013 at Minjar Shenkora District Agricultural and Rural Development Office (MSDARDO) and climate data from National Meteorology Agency from 1990 to 2020 and National Aeronautics and Space Administration (NASA) power data . 342 sample households were random selected from three kebeles (Wolde Giorgies, Bolo Sallsia and Korma) which are located at different agroecology. The data were analyzed using Statistical Package for Social Science (SPSS) version 26 and Rsoftware and Microsoft excel 2010. Multivarite regression anlaysis, correlation, trend analysis, Precipitatin concentration index, rainfall anomaly index, and coefficient variance and extreme rainfall and temperatures indices were used to anlyze the data. Mann-Kendall test estimate test were applied to identify the existing trend analysis. Accordingly, decrease in rainfall and an increase in temperature were recorded. Also, the results of Correlation Coefficients indicated that the duration of annual, summer, belg rainfall and Temperature had a strong positive, moderate negative, and weak positive relationship with teff, wheat, lentil, chickpea, and sorghum yield in the study area respectively. The multivariate regression analysis revealed that -20, 59, 47, 50 and 43% of the variance in teff, wheat, lentil, chickpea and soughum respectively could be explained by the climatic variables. The findings also revealed that rainfall and temperature variations have an impact on crop yield, but the impacts differ by crop in this district. Therefore, the farmers have used adaptation mechanisms such as ;- improving seed varieties, crop diversification, planting trees, soil and water conservation, changing planting dates, irrigation, water harvesting, and Growing short-maturing crops. Thus studies should be investigated on the impact of climate change and variability on major crop and its adaptation.