One of the numerous factors contributing to soil degradation, both chemically and physically, has long been thought to be land use change. This study was conducted to analyze land use/cover change over 31 years (from 1990 to 2021) and to evaluate the effects of land use types and soil depth on selected soil properties at the Embamamie micro watershed in northwest Ethiopia. Using software ERDAS Imagine 2015 and Arc GIS 10.7 were used to analyze the micro watershed Landsat satellite images of 1990, 2006, and 2021 download from USGS website center. Four land use types (natural forest, plantation forest, cultivated, and grazing lands) were selected for the determination of the effects of land use type and soil depth on selected soil properties. Both disturbed and undisturbed core soil samples were collected from two soil depths (0-20 and 20-40 cm). The soil samples wereanalyzed following the standard soil analytical procedures in the Bahir Dar university soil testing laboratory. The findings of the image analysis for the years 1990 to 2021 indicate that the area of cultivated land and settlement areas has grown by 25.63% and 3.24%, respectively at the expense of grazing and natural forest lands. The highest sand fraction (46.16%) and BD (1.27gcm-3) were recorded under cultivated land whereas the highest percentage of clay (63.4%), silt (17.66%), SMC (27.53%), TP (59.33%), pH (6.36), SOM (5.9), TN (0.3%), Av. P (2.65 mg/kg), CEC (46.27 cmol (+) kg-1) and exchangeable bases were recorded in the natural forest land. With soil depth, the sand fraction, TP, SOM, TN, Av.P, and CEC decrease with increased soil depth, whereas the clay, BD, SMC, pH, exchangeable bases and percent of base saturation increased with increasing soil depth. Inappropriate land use management led to disturbance of soil nutrient status, indicating that the soil condition in thecultivated land and plantation forest is getting below the condition of soils under natural forest and grazing lands.Therefore, proper land use plan and soil water conservation could maintain the existing soil condition and replenish degradedsoil properties.