The study was conducted to evaluate the effects of nutritional flushing on body condition score, body weight and reproductive performance of Doyogena ewes. Thirty five Doyogena ewes with initial body weight of 27.71±2.87 kg (mean ± SD) were used for the experiment. The experimental design was a randomized complete block design (RCBD) with five blocks consisting of seven ewes per block based on their initial body weight. The supplementary treatments were comprised of grazing natural pasture (T1), 340g enset leaf with 500g concentrate g/ewe/d (T2), 340g enset leaf with 500g concentrate g/ewe/d (T3), 340 g enset leaf with 400g concentrate g/ewe/d (T4) and 340g enset leaf with 250g concentrate g/ewe/d (T5) for 35 days. The ewes received flushing supplementation for three weeks before mating and two weeks after mating. All ewes were synchronized using an intramuscular injection of prostaglandin F2 alpha (PGF2α) on day 21 of the experiment and the ewes coming to heat were artificially inseminated. A general linear model (GLM) procedure of the statistical analysis system (SAS, version 9.2) was used to analyze body weight, body condition score, onset of estrus, duration of estrus, lambs birth weight, litter size, and gestation period. The estrus response rate, conception rate, lambing rate, and fecundity rates were analyzed using nonparametric test. The results showed that during mating and mid pregnancy period the mean body weight of the ewes were significantly (P<0.01) higher under (T2, T3, T4 and T5) than T1.Whereas, at lambing period the mean body weight of the ewes were highly significant (P<0.001) differences in (T2, T3 and T4) than T5 and T1. The mean body condition score of the ewes under (T2, T3, T4 and T5) was significantly (P<0.01) higher than that of T1. The onset of estrus was a highly significant (p< 0.001) under T3 and T4 than T1, T2 and T5. The mean time to duration of estrus under T3 and T4 showed longer duration of estrus than T1, T2 and T5. The result indicated that estrus response rate under T2, T3 and T4 had highly significant (P˂0.001) than T1 and T5; 100%, 100% and 85.7%; and 71.4% and 71.4%, respectively. The conception rate under T3 (85.3%) and T4 (83.3%) had significantly higher values (p<0.001) than T1 (60%), T2 (71.4%) and T5 (66.67%). The lambing rates of T3 (100%), T4 (100%) and T5 (100%) were significantly higher (P<0.001) than T1 (66.67%) and T2 (80%). The fecundity rate was highly significant (P<0.001) differences in T3 (157.1%) compared with T2 (100%) and T1 (60%). The litter size under T3 (1.83 ± 0.06) was highly significant (P<0.01) than T1 (1.50 ± 0.20), T2 (1.75 ± 0.11), T4 (1.60 ± 0.22) and T5 (1.50 ± 0.24). The birth weight of lambs under T3 (3.39 ± 0.097) and T4 (3.19 ± 0.106) were significantly (P<0.01) higher than T2 (3.04 ± 0.117), T5 (2.93 ± 0.091) and T1 (2.73 ± 0.088 kg), which could be attributed to high amount of nutritional flushing. Hence it was concluded that feeding 340g enset leaf + 500g concentrate and 340 g enset leaf + 400g of concentrate is ideal feeding regimen as compared to other treatment groups in order to achieve a higher body condition score, body weight and reproductive performance.