The purpose of this study was to examine the effect of organizational culture (OC) on employee performance with in the mediating role of employee engagement in Amhara National Regional State Trade and Market Development Bureau. In this survey study, 138 of the employees were used to collect quantitative and cross-sectional data using the census method. Utilizing modified structured questionnaires from earlier studies, the pertinent data was gathered, and the study's design was explanatory. The partial least square-structural equation model (PLSSEM) version 4 was used to test the hypothesis and SPSS version 26 was also used for descriptive statistics and correlation test. According to the results of the descriptive statistics, participants’ levels of agreement with regard to organizational culture, employee engagement, and employee performance were moderate. Based on the correlation analysis result organizational culture has a high degree of relationship with employee performance and employee engagement. Employee engagement has also a high degree of relationship with employee performance. The results of PLS-SEM confirmed that employee engagement partially mediates the connection between organizational culture and employee performance and organizational culture has a significant effect on employee engagement and employee performance. The finding of this study also showed that employee engagement directly affects employee performance. This indicated that a strong and successful bureaual culture will increase employee engagement in order to achieve employee performance and the goals of the bureau along a shared path. According to this result the study recommended that the management of Amhara National Regional State Trade and Market Development Bureau should include employees in the decision-making process, providing welfare for employees, and making policies that can influence the extent to which employees are involved. Strategic priority should be given to human development, good self-esteem, candor, and participation. This will significantly increase employee concentration on their predetermined goals, resulting in improved performance.