Good quality surface water is basic to human survival on earth. This study aimed at the effects of Dashen brewery effluents on the water quality of Shinta River. Water samples were collected from the river and brewery effluents along different points and analyzed for various physio-chemical and heavy metals quality. Effects of brewery wastewater on the river water quality were investigated. Water samples were collected from five sites on both river and wastewater and analyzed for pH, temperature, electric conductivity (EC), salinity, total dissolved oxygen, dissolved oxygen, biological oxygen demand, chemical oxygen demand, selected anions (nitrite, nitrate, phosphate) and some heavy metals (Fe, Mn, Zn, Cu, Cd, Ni and Pb). The levels of heavy metals were determined by use of flame atomic absorption spectroscopy (FAAS) and data analysis was achieved by use of ANOVA and t-test. The concentration of salinity, total dissolved solids, biological oxygen demand, chemical oxygen demand, nitrate and phosphate exceed the WHO and EPA effluent quality standard limits for these parameters in effluents to be discharged into a river but pH, temperature, EC, nitrite, and all heavy metals (Fe, Mn, Zi, Cu, Cd, Ni, and Pb) in effluents were within the world health organization (WHO) and environmental protection agency (EPA) guidelines. The mean level of pH, temperature, nitrite, and all heavy metals (Fe, Mn, Zi, Cu, Cd, Ni, and Pb) were within the permissible limit set by WHO and EPA guidelines but electric conductivity, salinity, total dissolved solids, biological oxygen demand, chemical oxygen demand, nitrate and phosphate were above WHO and EPA standards. Most of the parameters analyzed were within the world health organization (WHO) and Environmental Protection Authority (EPA) guideline standards for surface and waste water. The results of the correlation matrix analysis showed significant correlation between the variables at different sites. In addition, increasing order of pH, temperature, electric conductivity, salinity, biological oxygen demand, chemical oxygen demand, nitrite, nitrate, phosphate, Fe, Cu, Cd, and Ni level were observed from upstream to downstream sites. The results of the study proved deterioration of Shinta River water quality due to the discharged brewery effluent. Effective wastewater treatment and reuse is highly recommended.