This study examined the effect of perceived organizational politics on employees’ job satisfaction in selected public universities in Amhara National Regional State, Ethiopia. The study applied a quantitative research approach with an explanatory type that followed a postpositivist philosophy of research. To achieve the research objectives, the data were collected from a survey of 391 (out of 17,870 total populations) randomly selected academic and administrative staff members of the two purposively selected universities using a structured questionnaire. The multiple linear regressions along with descriptive statistics results generally showed that perceived organizational politics significantly influence employees’ job satisfaction in Bahir Dar University and the University of Gondar. The three dimensions of perceived organizational politics explained 60% of employees’ job satisfaction and 40% is explained by other factors. In this study, the research concluded that all dimensions of perceived organizational politics such as the general political behavior, go along to get ahead, and pay and promotion policies have a negative and statistically significant effect on employees’ job satisfaction. Finally, the researcher recommended that in order to improve such undesirable perception among their employees, universities should device strong and effective communication and relation program that can soften the possible tension in the employee-to-employee and employee-to-management relationships.