Everyone has the right to access to pharmaceuticals, and its effectiveness is substantially affected by the functioning of the health logistics system which has a goal that is much larger than simply making sure a product gets where it needs to go. In the past vertical logistics system of Ethiopia, there were a high rate of pharmaceuticals stock outs, high wastage rate etc throughout the health system of the country. To overcome these problems, the current pharmaceuticals logistics system, Integrated Pharmaceuticals Logistics System (IPLS), was designed with the objective of achieving the six logistics rights. Despite the previous limited studies in the area, this study was aimed at assessing the performance of IPLS in terms of its set objectives in selected health centers of Awi zone of Amhara region, Ethiopia. Descriptive crosssectional study design and quantitative method of data collection using standard logistics indicators were employed in the study. Structured Questionnaire was also used for the purpose of data collection which was adapted from the standard quantitative data collection tools, logistics indicators assessment tool and IPLS implementation supportive supervision tool. The Ethiopian pharmaceuticals supply chain system monitoring and evaluation indicators and national standards such as the National Minimum Standards for Health Centers were also used in the preparation and adaptation of quantitative data collection tools. The data were collected from 33 health centers of Awi zone which were in the first and second phases of IPLS implementation. It was found that all pharmaceuticals programs have been integrated into the IPLS except vaccines which had a different reporting-resupplying schedules and distribution system. Also, storage requirements had been met by a significant number of health centers. However, near to half of the health centers did not have sufficient storage space for its current pharmaceuticals demand. On the other hand, the supply system for pharmaceutical programs integrated into IPLS is generally a pull system except for maternal, neonatal and child health program. However, the supply system in use by sources other than Pharmaceuticals Fund Supply Agency (PFSA) was exclusively push system regardless of the type of program. Overall, the average availability of tracer pharmaceuticals was generally good. Generally, the average percentage of sustainable pharmaceuticals availability was found to be above the acceptable level. However, it was found that there were still challenges in reducing the pharmaceuticals wastage rate. Apart from this, the pharmaceuticals prices of PFSA were found to be relatively lower than other sources and there was also a fixed rate for determining the selling prices of pharmaceuticals at all health centers. Only less than half of the health centers were found to be included under direct delivery modality. In addition, about half of the facilities had an average lead time of above one month regardless of the supplier (PFSA or Woreda Health Office). It is recommended that stakeholders shall look for ways of integrating vaccines into IPLS and work towards improving the sustainable availability and storage conditions of pharmaceuticals. It is also proposed that responsible bodies should work towards shortening the pharmaceuticals delivery lead time to some health centers and design a mechanism for directly delivering pharmaceuticals requested as emergency to service delivery points.