Climate change adaptation is adjustment in ecological, social, or economic systems in response to actual or expected climatic stimuli and their effects or impacts. This study identifies different perception of farmers, examining different adaptation strategies currently used by farmers and the determinants that hinder to cop up climate change and variability in four kebeles of North mecha district. The study incorporates both primary and secondary data sources. Primary data were collected through structured and semi structured questionnaire from 138 respondents, focused group discussion, key informant interviews and field observation selected through stratified random sampling technique based on agro-ecology. Secondary data were collected from published and unpublished documents and, the Royal Netherlands Metrological Institute (KNMI) climate explorer 0.5 degree monthly observation. To analyze the result of the study Statistical Package of Social Science (SPSS) version 21and excel-2013 were used. Binary logit model was used to see the relationships between dependent and independent variables and multinomial logit model was used to examine the determinant factors of adaptation strategy. Based on farmer’s perception the results revealed significant increasing trend in annual average temperature and decrease annual rainfall trend as well as a higher rainfall variability. Among the interviewed farmers chi-square test showed a significant variation in perception to temperature and rainfall between gender, educational status and farming experience. The binary model results revealed that the main adaptation strategies of farmers include soil and water conservation, use improved variety, planting tree & agroforestry and use irrigation & water harvesting. Multinomial logit model revealed determinant factors such as, gender, age, family size, educational status, farming experience, access to extension service, access to climate information, lack of infra-structure, farm land size and financial problem which has a positive and negative impact on different adaptation strategies used by farmers in the district. Key Words: Perception, adaptation strategies, determinant factor, Climate Change, climate Variability, North Mecha