Abstract The integration of petrography and bulk rock geochemistry studies of the Adigrat Sandstone Formation in the Blue Nile Basin (BNB), NW Ethiopian plateau was investigated to infer their provenance, depositional tectonic setting and source area weathering of the studied sandstone samples. The total of threaten (13) representative fresh sandstone samples were collected from the study area for the petrographic and geochemical analysis. The bulk rock geochemical analysis were done by using the combined methods of Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for major oxides and trace elements including rare earth elements (REE), respectively. On the basis of petrographical and geochemical result the studied sandstone samples are classified as the lower Adigrat unit (reddish-brown) (Sublitharenite, Subarkose and Fe- rich sand), and the upper Adigrat unit (light to gray) (Quartzarenite, Sublitharenite and Subarkose) classes. Modal analysis of the upper unit Adigrat Sandstone samples indicate that the provenance was sourced from recycled orogen and cratonic interior, however the lower unit samples show sourced from recycled orogen. Based on the discrimination function diagram of major oxides indicates the provenance of upper and lower part of Adigrat Sandstone is quartzose sedimentary provenance which is derived from weathered granitic – gneissic or the pre-existing sedimentary sources. The selected trace elements and REE ratios (La/Sc, Th/Sc, La/Co and Eu/Eu*) and ratio plots (Th/Co vs. La/Sc and La/Th vs. Hf) infers the lower and upper unit of the studied sandstone sourced from felsic to andesitic rocks. The presence of higher value of LREE/HREE and the negative Eu anomalies (Eu/Eu*<1) in both part of the studied sandstone reveals felsic source rock. The paleo-weathering of the Adigrat Sandstone can be determined by different weathering indices (CIA, CIW, PIA and MIA), which indicate the source area of the Adigrat Sandstone was experienced intensive weathering condition. But, on the bases of MIA the lower part have moderate to intensive weathering. Based on the discrimination function diagram of major oxides and the ternary plot of trace element (Th-Sc-Zr/10 and Th-Co-Zr/10) infer the studied sandstone deposited pre-dominantly in passive margin setting. However the lower unit indicates that deposited in passive to active continental margin setting. Keywords: Blue Nile Basin, Adigrat Sandstone, provenance, tectonic setting and paleo-weathering.