The purpose of this study is to investigate factors affecting tax audit effectiveness in Amhara region tax auditors. The study aims to examine the statistical significance between factors and tax audit effectiveness. The study adopted quantitative method of research to test a series research hypothesis. Specifically, the study used survey of questionnaire of revenue authority tax auditors’ response. Simple random sampling technique was employed based on nature of the target population. Then, tax auditors were selected based on simple random sampling and lottery method respectively. Consequently, the study selected a sample of 79 with the total of 162 target population. Data was then analyzed on quantitative basis using Pearson's correlation, multiple regression analysis and descriptive statistics. Based on the findings of the analysis is strongly significant positive relationship among Organizational setting, top management support, auditee attribute, organizational independence and tax audit effectiveness. Hence auditee attribute, organizational independence, organizational setting, and top management support play significant role on the improvement of tax audit effectiveness, Amhara National Regional State Revenue Authority should be focused on that predictor.