Profitability is a situation in which an entity is generating a profit. Profitability arises when the aggregate amount of revenue is greater than the aggregate amount of expenses in a reporting period. The primary goal of this study was to empirically investigate the determinants factors of insurance company profitability in Ethiopian. A fixed effect regression model was use in the investigation. Ten insurance companies were taken as a sample. The researcher used a purposive sampling technique to select those Ten Ethiopian insurance companies. The data covers from the period 2013-2022 were used for analysis. The data was collected from national banks of Ethiopia, annual report of each insurance company and World Bank data. A Balanced longitudinal/panel secondary data set were used in this study. Also, Explanatory research design, quantitative research approach and positivism paradigm were employed to examine the effect of explanatory variables (size of the company, age of the company, tangibility of asset, equity ratio, liquidity ratio, cost efficiency, combined ratio, interest rate and inflation). The major findings of the study revealed that interest rate and combined ratio negative and statistically significant effect on Ethiopian insurance company profitability. Inflation rate has negative and insignificant effect on profitability of insurance company. Whereas age of the company, tangibility of asset, equity ratio, cost efficiency has positive and significant effect on Ethiopian insurance company profitability. Finally company size has positive and insignificant effect on profitability of insurance company.