Any attempt to increase the capacities of people who experience shocks from drought and food insecurity regularly must start with a basic comprehension of resilienceroots. The study focuses on households’ resilience to drought and shocks in SehalaSeyemt Woreda in Wag Hemra Zone, Amhara region. The study also investigated households’ food security status and their interaction with resilience and shocks. Theresearch employed a cross-sectional design with a mixed research approach. Thestudy area was selected purposefully. The woreda embraced thirteen KebelesHowever, the study selected three Kebeles randomly, and a total of 326 respondents were selected using a simple random sampling technique and allocated in proportionto the population size of the Kebeles. Two focus group discussions were also held each Kebele. The Standard Precipitation Index, multivariate stage confirmatory factor analysis, household multidimensional food insecurity index, and ordinalogistic regression model were employed to analyze the data. The StandarPrecipitation Index assessment indicated that drought in the study area had significantly risen between 1992 and 2022. From the confirmatory factor analysis, thehousehold asset index was the most critical positive factor with a factor loading 0.831 for households being resilient or not, followed by households’ access to basiservices with a positive factor loading of 0.819 and households’ adaptive capacitwith a positive factor loading of 0.75. A significant portion (73.31%) of the householdlies under moderate resilience and non-resilient status, and a sizeable portion (61%of the household has moderately and severely food insecure status. The interactiveffect of households’ resilience pillar and shock exposure on households’ food security status indicated that assets, access to basic services, and adaptive capacitpossess a negative and highly significant effect on households’ food insecurity statusand shock exposure has a significant and positive effect on households’ food insecurity status. This study revealed drought concerns affecting householdresilience and food security. Urgent interventions are needed to enhance resiliencand address evolving food security dynamics, emphasizing sustainable initiatives build household coping strategies to shock and bounce back better aftershockoccurrence. The findings contribute to the discourse on creating secure, sustainableinitiatives and a resilient future.