In Ethiopia, bread wheat is a significant cereal crop in terms of production volume and area coverage. However, its yield is influenced by yellow rust disease. Hence, this study was carried out to assess the status of yellow rust disease and to develop bread wheat yellow rust disease integrated management options using varieties and fungicides in Debre Elias district during 2023 main cropping season. A total of 100 wheat farmer fields were assessed from four kebele administrations in the district for yellow rust disease prevalence, incidence, and severity and the collected data were analyzed using SPSS version 25 software. The field experiment was conducted at Guay Kebele administration on a farmer’s field. A total of 9 treatment combinations, including three bread wheat varieties (Danda’a, Ogolcho, and Kakaba) and two fungicides (Nativo SC 300 and Kanzole 25% EC, including unsprayed check) with three replications were laid out in a factorial arrangement using RCBD design. Both disease and yield-related data were collected, and SAS 9.4 software was used to analyze them. Survey results revealed that 88%, 42.41%, and 28.67% of yellow rust mean prevalence, incidence, and severity were observed in the district respectively. Survey result also revealed that the highest mean severity was recorded on fields covered by Ogolcho variety (50.91%), which were at heading growth stage (31.48%), had high plant density (40.79%), previously covered by wheat crop (36.97%) with an altitude range >2167 m.a.s.l. (31.77%) and unsprayed ones (36.61%). The field study result showed that the highest FYRS of 89.08%, 80.48%, and 43.33% were recorded on unsprayed Ogolcho, Kakaba, and Danda’a varieties, respectively. And also the minimum (363.02% days -1 ) AUDPC value was registered on the Danda’a variety treated with Nativo SC 300 fungicide. Varieties of unsprayed plots resulted in maximum RYL of 74.55%, 52.31%, and 48.13% on Ogolcho, Kakaba, and Danda varieties, respectively. Variety Danda treated with Nativo SC 300 fungicide gave the maximum (4.55 t ha -1 ) of grain yield and NB (302,150 birr ha -1 ). As a result, the combined use of Danda variety with Nativo SC 300 fungicide could be suggested for efficient yellow rust management and optimization of production in Debre Elias. The study should be repeated in similar and differe nt agro-ecologies and years to set a solid recommendation.