Tomato is one of the most important vegetable crop in Ethiopia. Diseases are major constraints that limit production of tomato in the country. Late blight, caused by Phytophthora infestans, poses a significant challenge to tomato production in Ethiopia. This study evaluated the effect of host resistance and fungicide spray frequency on tomato late blight disease at Jawi District during the 2024 irrigation season. The design of the experiment was a randomized complete block design (RCBD) with factorial arrangements with three replications. Disease severity and incidence were significantly influenced by the treatments. The highest disease severity was observed on untreated plots, with value of 54.17% in Melkashola, while the lowest severity was recorded in Miya and Melkashola varieties treated with four times sprays (26.92% and 32.78%, respectively). The area under the disease progress curve (AUDPC) (value) and disease progress rates (value) were lowest in treated plots in plot specify it Yield losses reached up to 61.41% in untreated plots, whereas marketable fruit yield was maximized at 36.25 t ha⁻¹ in three-time fungicide-sprayed plots. Marginal analysis indicated that two applications were cost-effective for Miya and Roma VF, while three applications were optimal for Melkashola and Melkasallasa. The integration of resistant varieties and targeted fungicide applications effectively minimized late blight epidemics and enhanced yield. These findings suggest the adoption of integrated management strategies tailored to variety-specific resistance levels and for sustainable tomato production.