Sweet potato (Ipomoea batatas(L). Lam) is one of the widely produced root crops in Ethiopia. However, the yields are low due to many factors. Node number and intra- row spacing are among the agronomic factors that determine the productivity of Sweet potato. A field experiment was conducted to investigate the effect of node number and intra-row spacing on growth yield components and yield of sweet potato during 2024/2025 main rainy seasons at in Wangedam Kebele, Burie Zuria District Debre Markos University Burie Campus Menkorer private limited company farm land. Alamura variety of sweet potato was used as a test crop for the experiment. The experiment consisted of three types of node numbers (4, 6, 8 nodes) and four intra row spacing (25, 30, 35, 40 cm). It was laid out in 3x4 factorial combination are in randomized complete block design with three replications. Data collected from new shoot development, physiological maturity, vine length, inter-node length, vine number, above ground biomass, root length, root diameter, average weight of root per plant, unmarketable root number per plat, marketable root number per plant and total root yield. The collected data was subjected to ANOVA using SAS (9.4) software. The ANOVA result revealed that the main factor intra row spacing and node number and their interaction had a highly significant(P<0.001) effect on days to maturity, vine and internode length, vine number, aboveground biomass, root length and diameter, root number per plant, average weight of root per plant, marketable root number per plant and total root yield per hectare except above ground biomass for the interaction effect. The maximum root yield of 42.83 tha -1 ) was recorded from 8 node number vine cutting planted at distance of 30 cm intra-row spacing, while the minimum yield(20.97t/ha) was recorded from treatment combination of four nodes with 25 cm intra-row spacing. Therefore, in the study area and similar agro-ecologies sweet potato growers can use vine cutting with 8 nodes with intrarow spacing of 30cm that would improve the productivity of the sweet potato. However, since this study was conducted for a single season at one location, conducting multiyear and multi-location trials would help to make the results more reliable."