Potato is one of the most commonly cultivated crops in north Gondar. However, the productivity potato is very low as compared to the national average. Improper soil nutrient management is one of the major problems that contribute for this lower productivity. A field experiment was conducted at Debark university research site in 2024 irrigation season to determine the economically feasible rate of nitrogen and phosphorus fertilizer for the productivity of potato in the study area. Four levels of nitrogen (0, 92, 115 and 138 kg ha -1 ) combined with four levels of phosphorus (0, 23, 34.5 and 46 kg ha -1 ) were used as treatments. The experiment was laid out in randomly complete block design (RCBD) in factorial arrangement with three replications. The days to emergence, plant height, days to maturity, stem number, average tuber number, average tuber weight, marketable tuber yield, unmarketable tuber yield, total tuber yield, specific gravity, dry matter content and tuber starch content data was collected. R software version 4.4.2 were used for analysis of variance. The interaction of nitrogen and phosphorus was significantly affected the days to maturity, days to emergence and tuber starch content of potato. The plant height was very highly significantly (p≤0.001) and highly significantly (p≤0.01) affected by nitrogen and phosphorus respectively. Nitrogen fertilizer highly significantly (p≤0.01) increased the marketable and total tuber yield of potato. Higher marketable and total tuber yield of 32.71 t and 34.32 t ha -1 () were obtained with the application of 138 kg h -1 N. Phosphorus also significantly (p≤0.05) increased the tuber number, marketable yield and total tuber yield of potato. However, the interaction of nitrogen and phosphorus fertilization was not significant on the whole tested yield parameters except the unmarketable tuber yield. The highest dry matter content (23.43%) was recorded with 46 kg ha -1 of phosphorus application. Both nitrogen (p≤0.05) and phosphorus (p≤0.01) was significantly affected the specific gravity of potato. Phosphorus fertilization and the combined application with nitrogen were highly significantly (p≤0.001) affected the tuber starch content. The regression analysis indicated that for every one unit increase in nitrogen fertilizer rate (kg) there was a corresponding 62 kg potato tuber yield increment. There was an increasing trend in the yield with increasing of phosphorus rate, however, it was less pronounced than nitrogen. For quality centered production 46 kg ha-1 P and 92 kg ha-1 N gives the highest dry matter content and specific gravity. The maximum net benefit of 613,173 ETB with acceptable marginal rate of return of 152.36% was achieved by the combined application of 138 kg ha -1 of nitrogen and 46 kg ha -1 phosphorus and it can be recommended for the most profitable production of the potato crop for Debark and the areas with similar agroecology’s. In addition, the combined application of 115 kg N ha⁻¹ and 34.5 kg P ha⁻¹ offering net benefit of 602,644 ETB and an exceptionally high MRR of 8729.78%, it can be recommended as option for those with tight budget constraints.