Durum wheat is a major staple cereal crop in Ethiopia, but its yields and quality have been threatened due to Fusarium head blight (FHB). A field experiment was carried out at Debre Zeit Agricultural Research Center in the central Ethiopia during 2022 cropping season in order to manage FHB of durum wheat through integrated use of variety and fungicide application and increase quality seed production. The experiment consisted of 18 factorial treatment combinations of three fungicides (Unsprayed control, Propiconazole and Tebuconazole) and six durum wheat varieties (i.e., AlemTena, Utuba, Mangudo, Et Cross-21, Ude, and Tesfaye), laid out in randomized complete block design (RCBD) with three replications. Seed quality tests were conducted i n the seed laboratory using completely randomized design (CRD). Data on disease, growth, yield, yield-related and seed quality parameters were collected and analysis of variance was conducted using SAS version 9.0, and Tukey’s tests used for mean separation at 5%. Results revealed that the interaction effects of varieties and fungicides were significantly reduce disease and increase grain yield and seed quality parameters. The highest area under the disease progress curve (741.53% per day) on variety Ude with control (unsprayed). The highest yield (4.63 t/ha) were recorded on variety Et cross-21 with sprayed Tebuconazole. Lowest grain yield was recorded from variety Alem-Tena (2.29 t/ha) with control (unsprayed). FHB infected seed germination test result under standard, based on minimum seed certification standards of wheat in Ethiopia (85%). In this study, highest net benefit was obtained with treated Tebuconazole on variety Et cross-21. Hence, this can be suggested for the study area. However, the study was done in a single location and season. Therefore, additional location and season may be required to advance a comprehensive recommendation as best fusarium head blight management option.