Currently, there is no reliable and sustainable power supply for the Felegehiot specialized hospital. The electric power fluctuation for the hospital is critical problems and the standby diesel generator operation fuel cost is increasing time to time & requires frequent maintenances, due to this, it is not affordable to such power supply sources. The hospital has several departments, including ICU, major OR, dialysis, Gayne, and OPD. The total load demand is scaled approximately to 2426 kWh/day, considering other requirements. This power fluctuation needs another alternative energy source to solve power fluctuations and to supply reliable power. Hence, solar irradiation and wind resources have played a crucial role in sustainable electricity generation. However, access to reliable electricity remains a challenge, especially for healthcare centers, hospitals like Felegehiot hospital. This study identified the solar and wind potentials for the study area to generate renewable energy system as per the demands. It has been reviewed different literatures and we gather solar and wind potentials for the site using data collection includes information from NASA and the National Meteorology Service Agency (Bahir Dar branch). MATLAB Simulink software has been used for modeling and simulation of the hybrid system and fuzzy logic control is used to enhance the power generation efficiency, stability and reliability for each instant time. The Homer software is used for optimization and financial analysis in the case study area. The power share for this research is 80% solar and 20% for wind energy. The optimized output for average peak load demand is 203 kW. The maximum solar PV capacity is 470 kW, the rated capacity for 2 wind turbine energy is up to 180 kW and the battery capacity is 460 Ah at 12V. The battery capacity is designed for at least two days of backup power for selected critical loads and the lighting system. The optimal hybrid system includes solar PV, wind energy, a converter, and a battery system control strategy. The initial investment cost for PV, battery, and converter components is $1,194,630.05. The net present cost of the entire system over its lifetime is $2,115,925.24 The Levelized COE is calculated at $0.194 per kWh for Felegehiot Comprehensive Specialized Hospital. The optimized configuration is solving the power supply problems for the hospital. Based on the analysis, the solar PV-wind-battery system is a feasible solution to address the institution’s power demand challenges. Keyword: photovoltaic, Homer software, Mat lab, wind energy, Optimization