The study examined the risk communication practice of Amhara Regional State Health Bureau in the context of Corona virus pandemic. The researcher used qualitative approach and also employed Focus Group Discussion, in-depth interview and document analysis as tools to generate relevant qualitative data pertaining to the issue in focus. The Amhara Regional Health Bureau applied different communication methods and COVID-19 prevention activities during the outbreak. The Bureau organized a task force called risk communication and community engagement case team which focusing on surveillance, case management and logistics, hygiene and sanitation and emergency health communication. This team was directed by the Bureau public relations department. However, factors like culture, attitude and risk perception of the community brought challenges to the communication practice during the pandemic. The finding of the qualitative study revealed that the COVID-19 prevention measures were not fully implemented and that the practice varied depending on the people understanding. There were misconceptions and disinformation during the continuous implementation of COVID-19 preventive measures. Social media has aggravated the dissemination of these myths that further intensified the confusion among the public. This ineffective communication process related to the lack of trust in the government‘s preparedness and ability to respond to the pandemic. Factors that affected the risk communication of the pandemic also analyzed. The study recommended that the regional health Bureau public relations department needs to have well organized risk communication plan that considered the public‘s attitude, perception and cultural and religious activities.