Regular physical activity is widely recognized as a crucial component of a healthy lifestyle. Mainly aerobic and combined exercises have wide-range of health benefits. This study aims to compare the effects of 8 weeks of aerobic (MIAE) and a combination of aerobic with resistance exercise (CEX) on selected physiological variables among female university students. The study involved 32 non-athlete female students’ age of MIAE (22.188 ± 0.8342) and CEX (22.13 ± 0.719) years who participate 3 days/week for 8-week in MIAE and CEX training. The study design was a true experimental pre post design, and comprehensive sampling technique applied to select participants. The measured variables were blood pressure, resting heart rate, body fat percentages, and lean body mass. Finally, the data analyzed through a pair sample t-test and MANOVA with 95% confidence interval. The finding confirms that MIAE group found significant decreases in BP, RHR, and BF%, p<0.05 but no significant change on LBM (p=0.729). In CEX group demonstrated that reductions in BP, RHR and BF%, and increase in LBM (p < 0.05). CEX group was found better significance mean changes than MIAE in BP, BF%, and LBM. There was a statistically significant difference between MIAE and CEX on the combined set of physiological variables, F(10, 21) = 3.003;p =0.016; Wilks’ Lambda ()=0.411;partial eta squared(η² )=0.589. The Univariate contrast effect for each measure variable shows a significant effect on RHR: F (1, 30) = 6.182; p = .019 with (partial η² =.171) and LBM also statistically significant, F (1, 30) = 4.755; p =.037; (partial η² =.137). In conclusion, CEX was shown great statistical significant difference than MIAE on LBM, SBP, DBP and, BF% whereas MIAE showed a more significant reduction in RHR than CEX. Moreover, there were significant differences between MIAE and CEX groups only on RHR and LBM. Whereas there was insignificant difference between MIAE and CEX groups on SBP, DBP, and BF % on multivariate analyses results.