The wastewater produced in many different operations in the pharmaceutical industry are considered as an environmental problem because of their hazardous and potential impacts on the aquatic ecosystem and human. Among various pharmaceuticals, antibiotics attract significant attention in wastewater due to their eco-toxicological effects and the potential for the development of antibiotic-resistant bacteria. This thesis focuses on the selection of amoxicillin from the penicillin group, and existing studies indicate that single treatment strategies are often ineffective in removing this pharmaceutical. In this study, the removal of amoxicillin from wastewater by combination of electrocoagulation and photo-Fenton processes was investigated. Response Surface Methodology (RSM) was used to assess the impact of key parameters and optimize all influencing factors through Box–Behnken design. For the optimization of the initial experimental conditions, drug degradation and chemical oxygen demand (COD) removal are measured as the objective parameters. All parameters determined using the methodology established in the standard method for the examination of water and wastewater. Under optimized conditions of Photo-Fenton process complete degradation (99%) and 80% COD removal were achieved at an initial amoxicillin concentration of 65 mg/L, Fe2+ concentration of 33 mg/L, H2O2 concentration of 219 mg/L, pH of 3.0 and reaction time of 60 min. In addition, in electrocoagulation process maximum amoxicillin removal 87% were found at pH 7.5, current density of 0.9A and reaction time of 38 min. The performance of combined processes was investigated by using optimum conditions of individual processes and exhibited an impressive AMO degradation efficiency of 100% and COD removal efficiency of 95%. In real wastewater also reached 98% amoxicillin removal and 88% COD removal at optimum conditions. This efficient degradation process shows the effectiveness of the combined Photo-Fenton and electrocoagulation approach in removal of amoxicillin. Keywords: Pharmaceutical, Amoxicillin, Advanced Oxidation Processes; photo-Fenton; optimization; Electrocoagulation