The greenhouse effect is attributed to the effects of global warming and the effects are being felt worldwide. The total CO 2 emissions related to cement production represent around 8% of the annual global CO 2 emissions and due to burning of fossil fuels and the manufacture of cement Ethiopia has released 0.16381 metric tons of CO2 in 2019, and being expected that cement manufacturing could reduce about 18% of their direct emissions by 2050. Due to non-biodegradability nature of glass waste, it has many negative effects on the environment when it is dumped in the landfills, and due to containing of very fine particles, marble waste being one of the environmental problems around the world. Due to industrial wastes are pollutants when discarded into land or thrown into water bodies, blending them in concrete production is safe disposal method for them and it is best solutions for sustainable development. So the main objective of this study was investigating the effect of partial replacement of cement with Waste Glass powder, Waste Marble powder and Scoria powder in quaternary blended cement mortar, in order to see the effect of partial replacement of cement with Waste Glass powder, Waste Marble powder and Scoria powder in quaternary system. The effect of the blended materials on the physical, fresh, hardened, durability, and microstructural property of concrete was investigated using consistency, setting time, workability, compressive strength, Sulfate resistance, Fourier Transform Infra-Red, Thermo gravimetric Analysis, and Differential Thermal Analysis tests. The water-to-binder (w/b) ratio of 0.5 was used for all mortar mixes produced. The Ordinary Portland cement was replaced up to 40% (10%, 20%, 30%, and 40%) by varying the amount of Waste Glass powder, Waste Marble powder and Scoria powder, and were tested at the ages of 3, 7, 28, 56, and 90 days. Mix G (20%) 5WGPWMP10SP) was an optimum in terms of compressive strength, sulfate resistance and microstructure with standard setting time and workability, and mix B (10%) 5WGP2.5WMPSP) was an optimum in terms of workability. According to the experimental result, replacing the Ordinary Portland cement up to 30% is recommended. Keywords: Ordinary Portland cement (OPC), Waste Glass Powder (WGP), Waste Marble Powder (WMP), Scoria Powder (SP), Fresh Properties, Mechanical Properties, Durability, Microstructure.