The main purpose of this study was to explore the challenges of marriage among persons with disabilities in Amhara Regional State, Wegera Wereda. The data was collected from persons with disabilities,their families and care givers through semi structured interview and focus group discussions. Fifteen persons with disabilities and ninefamily members and caregivers were selected by purposive sampling technique. Hence, as persons with visual impairment and and physical impairment meet the criterias of the researcher that those are aged to marry, eight persons with visual imparment and seven persons with visual imparets were selected. The collected data were analyzed by using thematic analysis techniques. In doing so, procedures including organizing, reading the transcribed data, coding, developing themes, representing and reporting themes, and finally interpreting meanings of findings were practiced. The findings of the study reveal that persons with disabilities face varieties of problems when they want to marry. Accordingly, economical, attitudinal, environmental and educational challenges were major challenges for persons with disabilities. In addition, the data shows that females were more challenged than males with disabilities because of poor expectation of communities and having high responsibilities of child rearing and other responsibilities at home. In order to overcome marriage related challenges, those persons with disabilities practiced their on coping mechanism like building good relationships with societies, accepting diversity and asking for support from families and others as any human beings seeks such support. The study finding implicates that community’s misunderstanding and low expectation towards persons with disabilities affects their participation in marriage. Therefore, the stake holders like social affairs and others such as experts in persons with special needs should give awareness raising trainings for communities and those persons with disabilities for the purpose of creating social inclusion and eliminating challenges to marriage of persons with disabilities.