Team handball combines skills of running, jumping, catching, and throwing into a fast-moving, exciting game. Training with a medicine ball is one way to increase a person's general fitness as well as their fitness for a particular sport (Actor et al., 2021). But there is not enough literature on the effect of medicine ball training on grip strength and the handball skill performance. The purpose of this study was to investigate the effects of medicine ball training on hand grip strength and some selected handball skill performance of female under-17 handball project trainees. The population was little in number and then taken as a sample by using the compressive sampling technique. The subjects of the study were twenty (N=20) and randomly assigned to experimental (N=10) and control (N=10) groups. The experimental group participated in an 8-week medicine ball training program, 2 days per week for 60 minutes, in addition to the regular training session, whereas the control group participated only in the regular training. The data was collected through a strength test and field skill test and this data was analyzed by using paired sample t-test and independent sample t-test statistical tool SPSS version 26 with a significance level of 0.05. Based on the data analyzed through paired sample t-test, EG significantly increased in hand grip strength, (p= 0.000) shooting accuracy, (p= 0.001), and speed dribbling, (p= 0.000) but no performance improvement in throwing accuracy, (p=0.343). Similarly, the independent t-test shows the post-test performance of hand grip strength, shooting accuracy, and speed dribbling of EG was significantly improved than the post-test result of CG (hand grip strength, p=0.001, shooting accuracy, p= 0.028, and speed dribbling, P=0.000), but not throwing accuracy (p=0.911, p>0.05)). The experimental group improve hand grip strength, shooting accuracy, and speed dribbling compared to the control group (p<0.05). Therefore, it can be concluded that medicine ball training improves hand grip strength, shooting accuracy, and speed dribbling of female u-17 handball project trainees. Whereas medicine ball training had not improved in throwing accuracy skill performance of u-17 female handball project trainees.