Background: Patients' perception of nursing care indicates clients’ emotion on the nursing care they have received which is used to provide essential and holistic information on the overall quality of nursing care. And there was no study that has been conducted in Ethiopia that explores patients' perception toward nursing care through in-depth patient interviews. Therefore, this study was attempted to fill this gap. Objective: The study's objective was to evaluate how patients felt about nursing care and the contributing factors in adult inpatient departments in comprehensive specialized hospitals of Northwest Ethiopia's, 2023. Method: An institution based Concurrent triangulation design was conducted with data collection period from March 20,2023 to April 27, 2023. Participants were selected for the quantitative component using a systematic random sampling procedure, and the principal investigator performed an in-depth interview with patients who had been purposefully chosen till saturation level for the qualitative part. Epi Data version 4.6 was used to enter the quantitative data, and SPSS version 25 was utilized to analyze it whereas descriptive and inferential statistics were then employed for analysis. Binary logistic regression was used to assess the association among dependent and independent variables in the quantitative data, while qualitative component was triangulated with quantitative part after it has been thematically analyzed. Result: The study included 602 admitted patients in total. Of those, 50% of participants had good perception of nursing care. Good perceptions of Patients' on nursing care were significantly associated with previous hospitalization history (AOR = 0.42; 95% CI: 0.29- 0.63), admission to medical wards (AOR = 0.43; 95% CI: 0.27- 0.69), and staying less than seven days in a hospital (AOR = 1.50; 95% CI: 1.03- 2.20). Conclusion: This study found a significant association between patients' perceptions of nursing care and prior hospitalization history, admission wards, and the length of time the patient spent in admission, as well as that one in two patients have a poor perception of nursing care. Hence, hospitals should implement methods to improve patients' perceptions of nursing care and frequently evaluate nursing care. Key words: Associated factors, Inpatient Department, Nursing Care and Patient’s Perception