Introduction: The importance of hospitals in disaster preparedness cannot be overstated, yet the lack of adequate hospital preparedness has had devastating consequences worldwide. In recent times, Ethiopia has witnessed instances where hospitals struggled to cope with the influx of casualties during disaster events. It is based on the authors' own firsthand experience as physicians, encountering difficulties in providing care to patients affected by such incidents, that this study was initiated. Objective: To assess the level of disaster preparedness and explore barriers for disaster preparedness among hospitals of Bahirdar city, in Amhara regional state, Ethiopia from January to April, 2022 GC. Method: A facility-based, cross-sectional study was conducted in hospitals in Bahir Dar city, Ethiopia. The study followed a sequential design, starting with a quantitative assessment of hospital preparedness and later incorporating qualitative analysis to explore barriers. The WHO hospitals' disaster preparedness assessment tool was used to evaluate the hospitals' preparedness status. Qualitative data were collected using semi-structured interviews. All seven hospitals in the city were included in the quantitative study using a census sampling approach, while purposive sampling was employed for qualitative data. Descriptive statistics and content analysis were used for data analysis.. Result: Result: The average disaster preparedness score of the assessed hospitals in Bahir Dar city was 102±19.6 SD, with a range of 50. Overall, the hospitals in Bahir Dar city were categorized as insufficiently prepared. Qualitative analysis revealed five categories and 16 subthemes of barriers related to disaster preparedness in these hospitals. Conclusion In comparison to global and national standards, it was determined that the hospitals in Bahir Dar City lack preparedness to effectively respond to disasters. Additionally, various factors at the governmental, institutional, financial, human resource, and infrastructure levels were identified as potential barriers to hospital preparedness.