Soil-transmitted helminths (STHs) like Ascaris lumbricoides and hookworm are a widespread problem, particularly in rural areas worldwide. In Ethiopia, children receive annual mass drug administration (MDA), but the prevalence of A. lumbricoides and hookworm infections is high, possibly due to albendazole's reduced efficacy. This study assessed albendazole's efficacy for treating A. lumbricoides and hookworm infections in two primary school students at Quhar Michael Kebele, also exploring the prevalence, intensity, and associated risk factors with infections. A mixed (experimental and cross sectional) study design was taken in February to March 2023 in two primary schools located Quhar Michael Kebele in Fogera district. The stool samples from the students and the risk factors for hookworm and Ascaris lumbricoides infections were collected. The author used Kato-Katz techniques to examine and count helminth eggs. Data were entered in Excel 2016 and analyzed using SPSS version 25, employing logistic regression tests (P < 0.05 for significance). 463 students (53.3% female, 46.7% male) were participated for this study. The prevalence of A. lumbricoides and hookworm infections was 25.3% (117 cases) with light intensity. Albendazole achieved cure rates of 92.6% (A. lumbricoides) and 88.3% (hoo kworm), with egg reduction rates of 91.1% and 86.8%, respectively. Both (Ascaris lumbricoides and hookworm) infections of the intensity were light. Factors significantly associated with A. lumbricoides infection included mothers' lack education (AOR = 7.08; 95% CI = 1.88-26.76; P = 0.004), fathers' lack education (AOR = 2.63; 95% CI = 1.09-6.36; P = 0.032), school latrine non usage (AOR = 6.43; 95% CI = 2.51-16.44; P < 0.001), untrimmed fingernails (AOR = 4.48; 95% CI = 1.51-13.28; P = 0.007), not washing hands after toilet use (AOR = 4.73; 95% CI = 1.25-18.0; P = 0.023), no handwashing before eating (AOR = 4.06; 95% CI = 1.87-8.85; P <0.001), and the absence of handwashing facility at home (AOR = 3.69; 95% CI = 1.63-8.38; P = 0.002) and hookworm infection included age between 10-14 (AOR = 2.08; 95% CI = 1.04-4.15; P = 0.038), irregular wearing of shoes (AOR = 17.7; 95% CI = 6.78-45.93; P < 0.001), and not washing hands after toilet use (AOR = 4.78; 95% CI = 1.69-13.51; P = 0.003). Efficacy against infections remained uncertain, with moderate prevalence. Hygienic practices, and consistent shoe-wearing are crucial for prevention. Administering double or triple doses essential to reduce the infections. Keywords: Cure rate, efficacy, egg reduction rate, primary schools, Quhar Michael, risk factor