dc.description.abstract |
Soil-transmitted helminths (STHs) like Ascaris lumbricoides and hookworm are a widespread
problem, particularly in rural areas worldwide. In Ethiopia, children receive annual mass drug
administration (MDA), but the prevalence of A. lumbricoides and hookworm infections is high,
possibly due to albendazole's reduced efficacy. This study assessed albendazole's efficacy for
treating A. lumbricoides and hookworm infections in two primary school students at Quhar
Michael Kebele, also exploring the prevalence, intensity, and associated risk factors with
infections. A mixed (experimental and cross sectional) study design was taken in February to
March 2023 in two primary schools located Quhar Michael Kebele in Fogera district. The stool
samples from the students and the risk factors for hookworm and Ascaris lumbricoides infections
were collected. The author used Kato-Katz techniques to examine and count helminth eggs. Data
were entered in Excel 2016 and analyzed using SPSS version 25, employing logistic regression
tests (P < 0.05 for significance). 463 students (53.3% female, 46.7% male) were participated for
this study. The prevalence of A. lumbricoides and hookworm infections was 25.3% (117 cases)
with light intensity. Albendazole achieved cure rates of 92.6% (A. lumbricoides) and 88.3% (hoo
kworm), with egg reduction rates of 91.1% and 86.8%, respectively. Both (Ascaris lumbricoides
and hookworm) infections of the intensity were light. Factors significantly associated with A.
lumbricoides infection included mothers' lack education (AOR = 7.08; 95% CI = 1.88-26.76; P =
0.004), fathers' lack education (AOR = 2.63; 95% CI = 1.09-6.36; P = 0.032), school latrine non usage (AOR = 6.43; 95% CI = 2.51-16.44; P < 0.001), untrimmed fingernails (AOR = 4.48; 95%
CI = 1.51-13.28; P = 0.007), not washing hands after toilet use (AOR = 4.73; 95% CI = 1.25-18.0;
P = 0.023), no handwashing before eating (AOR = 4.06; 95% CI = 1.87-8.85; P <0.001), and the
absence of handwashing facility at home (AOR = 3.69; 95% CI = 1.63-8.38; P = 0.002) and
hookworm infection included age between 10-14 (AOR = 2.08; 95% CI = 1.04-4.15; P = 0.038),
irregular wearing of shoes (AOR = 17.7; 95% CI = 6.78-45.93; P < 0.001), and not washing hands
after toilet use (AOR = 4.78; 95% CI = 1.69-13.51; P = 0.003). Efficacy against infections
remained uncertain, with moderate prevalence. Hygienic practices, and consistent shoe-wearing
are crucial for prevention. Administering double or triple doses essential to reduce the infections.
Keywords: Cure rate, efficacy, egg reduction rate, primary schools, Quhar Michael, risk factor |
en_US |
dc.title |
Efficacy of Albendazole, Prevalence, Intensity, and Risk Factors Associated with Hookworm and Ascaris lumbricoides Infections among Students in Two Primary Schools at Quhar Michael Kebele, Fogera District, Amhara Region, Northwest Ethiopia |
en_US |