Many governments, policymakers, international aid agencies, and developmental organizations distributed millions of dollars for reducing the impact of food insecurity in developing countries including Ethiopia. Mekiet is one of the districts in Amhara region which is highly prone to food insecurity. At present, one of the solutions to reduce food insecurity is building resilience at households’ level. Therefore, this study aims to address the rural household resilience to food insecurity in Mekiet District. This study assess the dimensions of rural household resilience to food insecurity and analyze the relationships of RIMA and TANGOs measures of resilience. Crosssectional research design was conducted in two agro ecological zones of Mekiet district from kolla and woyna-dega involving 228 respondents. The study employed mixed method research, whereby both quantitative and qualitative approach were applied. Multi-stage sampling techniques were employed to select the district, kebeles and sample households. Descriptive statistics, factor analysis, and structural equation model were employed to analyze the data. The result from structural equation modelling in RIMA approach showed that the latent variables of adaptive capacity, asset, and social safety net have value of (-1.45), (-0.66), and (-0.99), respectively, those are significant and strong negative values. On the other hand, access to basic service is significant and positive value of 1. The result from factor analysis in TANGO approach showed that the latent variables of absorptive and adaptive capacity has a load of 0.98 and 0.79 respectively. On the other hand, transformative capacity is found to be negative load (-0.78), all variables are found to be statistically significant. The mean household resilience capacity index in RIMA or TANGO methods are 0.54 and 0.51 respectively. Thus, both approaches are fairly similar. Therefore, households that own better access to RIMA and TANGO dimensions are found to be highly resilient to food insecurity. The study recommends, the resilience programs should be implement at district, community, and households levels to enhance household resilience to food insecurity.