Back ground: patient-centered care is defined as care that respectful of and responsive to individual patient preferences, needs, values, and ensuring that patient values guide all clinical decisions. Services that lack patient-centered care lead to unimproved health status, decreased patient and family satisfaction, and poor patient outcomes. Objective: This study is aimed to assess patient centered care practice and associated factors among patients admitted to public hospitals of west Gojjam zone located in, northwest Ethiopia, 2022. Methods: Hospital based cross-sectional study was conducted at public hospitals in West Gojjam Zone from May 15 to June 17 2022. A total of 604 participants were selected by using multistage supported by systematic sampling technique. Data were collected by Interviewer administered structured questionnaire. And entered to Epi-data software version 4.6 and exported to SPSS version 25.00 for analysis. Binary logistic regression analysis was carried out to identify associated variables, and potential confounders were controlled using a multivariable logistic regression model, and adjusted odd ratio (AOR) with 95% CI and p-value of less than 0.05 was considered significant variables. Result: Over all, 587 patients participated in this study making a response rate of 97.2; half of the study participants (52.3%) received good patient centered care (95% CI 48.3%- 56.4%). Social well-being (AOR: 1.78, 95%CI: 1.19-2.65), routine checkup (AOR: 2.87, 95%CI 1.93-4.27), consultation and empathy (AOR: 1.62, 95% CI 1.08-2.44), communication on safety alert (AOR: 2.15, 95%CI 1.30-3.54), and severity of illness (AOR: 12.76, 95%CI 5.19-31.37) were positively associated with patient centered care. While primary education (AOR: 0.52, 95%CI 0.33-0.77), and length of stay (AOR: 0.23, 95%CI 0.14-0.38) were negatively associated with patient centered care. Conclusions and recommendation: Overall, nearly half of adult hospital patient‘s good patient-centered care practice. This study was showed that PCC practice low compared to other studies conducted in our country and low- and middle-income countries. Social wellbeing, routine checkups, consultation and empathy, communication of safety alerts, and severity of illness were all significantly associated with patient-centered care. Therefore, concerned bodies should focus on enhancing patient-centered care by exerting positive influence over variables that are crucial service enablers. Keywords: patient centered care, public hospitals, Ethiopia.