The purpose of the paper as to examine the determinant factors affecting the success of micro and small enterprises (MSEs) in Jigjiga City, Somali Regional State. To examine the determinant factors, the thesis has adopted quantitative research approach. Both descriptive and explanatory research designs were used in the thesis. MSEs in Jigjiga city administration were purposely selected on the basis of time preference and location accessibility. Two sub city administrations were selected among the four sub-cities randomly by using lottery method including Karamara and Dudahidi. Stratified random sampling was used to get information from different sizes of the MSEs. The total populations of the study were 1193, of which 299 samples were used, determined using Yemane formula. The result revealed that financial factors, marketing factors, managerial factors and entrepreneurial factors are found to have significant impact on the success of micro and small enterprises in Jigjiga city. Hence, it is recommended that the city administration should emphasis on the factors mentioned to have positive contribution on the success of micro and small enterprises.