Introduction: Necrotizing enterocolitis is an acute inflammatory necrosis of the bowel disease which is a leading cause of neonatal mortality and morbidity. It is a life threatening medical disorders, which accounts 30% of neonatal death and also increased risk of poor health outcomes. Despite advances in neonatal intensive care unit interventions, necrotizing enterocolitis related mortality is still remains high. Objectives: The aim of this study was to determine time to death and predictors among Neonates admitted with Necrotizing Enterocolitis in public comprehensive specialized hospitals of Bahir Dar city, Northwest Ethiopia, 2022. Methods: An institution based retrospective follow up study design was conducted among 491 neonates admitted in neonatal intensive care unit from July 08/2019 to July 07/2021 at Bahir Dar City comprehensive specialized hospital. The data were collected by three BSc and one masters nurses. The study units were selected by simple random sampling technique from sampling frame. The data extraction period was from May 13/2022 up to June 12/2022. The data quality was assured by given training for data collectors and pretest was done at Felege Hiwot comprehensive specialized hospital. The data was entered in to Epi data version 4.2 and was exported to STATA version 14.1 software for analysis. Cox proportional hazard model was used for analysis at 95% confidence interval and 5% level of significance to identify independent predicator variables. Result: From a total of 491 reviewed charts, 477 neonates diagnosed with Necrotizing enterocolitis were included in the study that provided completeness rate of 97.15%. Among 477 study participants, 166 (34.8%) death was occurred during the follow up period. The overall incidence density rate during the cohort was 5.2 (95% CI=4.52 - 6.13) per 100 day of observation. Being low birth weight (AHR: 2.53, 95% CI: 1.38-4.62) respiratory distress (AHR: 1.68, 95% CI: 1.16-2.43), neonates on continuous positive air way pressure (AHR: 2.20 95% CI: 1.42-3.42), neonatal resuscitation (AHR: 2.12 95% CI: 1.32-3.40), and stage of necrotizing enterocolitis (AHR: 3.05 95% CI: 1.83-5.07) were significantly associated with death related to necrotizing enterocolitis. Conclusion: The overall incidence density rate in this study was high. Birth weight, respiratory distress, neonates on continuous positive air way pressure, neonatal resuscitation, and stage of necrotizing enterocolitis were significant predictors of time to death. Key words: Necrotizing enterocolitis, neonate, and time to death, predictors neonatal intensive care unit and Bahir dar