Introduction: Patient centered health care is care focused on the patient with the collaboration of health professionals and health care organizations in the way of patient preference. The application of patient centered health care practice is a common problem around the world, including in Ethiopia. Therefore, knowing patients’ perception on patient centered health care practice is an important input for institutions, patients as well as for health care providers. Objective: To assess patients’ perception on patient centered health care practice and identify its associated factors among public and private hospitals at Bahir Dar city, 2021/22. Methods: Facility based comparative cross-sectional study was conducted among public and private hospitals in Bahir Dar city from May 8–June 15, 2022. Using a multistage sampling approach, the study participants were selected. An interviewer-administered questionnaire was used to collect the data, which was then entered into Epi-data version 4.6 and exported to SPSS version 25. Bi-variable and multivariable logistic regressions were used to analyze the data. The odds ratio with a 95% CI at a p-value <0.05 was used to declare the significance level. Result:A total of 600 private and public hospital admitted patients were included in the study. About 66.3% of public and 40.3% of private hospitals had poor patient centered health care practices.Hospital type(AOR = 1.74; 95% CI [1.0-3.0]), Length of stay (AOR = 4.2; 95% CI [1.1,15.3]) and (AOR = 4.3; 95% CI [1.4,13]), knowing care providers (AOR = 2.4; 95% CI [1.2, 4.6] and (AOR = 3.9; 95% CI [1.1-9.6]), privacy care (AOR = 4.2; 95% CI [1.93, 8.9] and (AOR =3.3;95%CI:[1.5-7]),serviceeasiness(AOR=2.76;95%CI:[1.33,5.74)and (AOR=3.8;95%CI:[1.15, 12.7], were associated with poor practice in public and private hospitals respectively. Awareness of the disease (AOR = 2.3; 95%CI [1.12, 4.8]), information on plans of care (AOR = 4.6; 95%CI [1.9, 10]) and being involved in decisions (AOR = 2.7; 95%CI [1.28, 5.9]) were associated with poor PCHCP in private hospitals. The following factors were associated with Poor perception in public hospitals: residence (AOR = 2.9; 95%CI: [1.4, 5.5]), medication information (AOR = 2.88; 95%CI: (1.34, 6.2), and external appearance (AOR = 2.27; 95%CI: 1.04, 4.97). Conclusion & recommendation: This study reveals that, nearly more than half of patient perceived poor patient centered health care practice. Length of stay, knowing care providers,privacy care, awareness of the disease, and service easiness were found as associated factors. Therefore, hospitals better to give special attention to improve patient care and train healthcare. Key words: Patient centered health care practice, Public hospitals, Private hospitals, Ethiopia