Introduction: Globally, injury is a major public health problem and contributes to 16% of the global burden of diseases and 10% of deaths. In Ethiopia, like other developing countries, injury is a common public health problem. However, it is not well investigated in our study area. Therefore, this study will fill the gap by identifying the magnitude and associated factors of injury at emergency settings. Objective of study: The aim of this study was to determine the magnitude of injury and its associated factors among patients visiting emergency department of Debretabor referral hospital. Methods: An institutional based cross-sectional study was conducted among 418 clients from April/01/ 2022 to May/01/ 2022. The systematic random sampling technique was employed to select the study participants. Data was collected using semi structured interviewer administered questionnairebased on WHO guidelines. Data was entered and analyzed using SPSS version 25.0 software package. Bivariable and multivariable logistic regression analysis were used to assess the association between dependent and independent variable. A 95 % CI and p –value of < 0.05 was used to measure the statistical significance of association.Model adequacy was cheeked by Hosmer and lemeshow (0.866) and well fit the data. Result: The proportion of injury was 41.3 %. Being male (AOR = 2.156; 95 % CI, 1.420-3.274),age 20-45 (AOR = 1.934; 95 % CI, 1.139-3.283), income less than 34.2 USD (AOR = 3.225; 95 % CI, 1.759-5.911),occupation; daily laborers (AOR = 7.255;95 % CI, 2.782-18.923), marital(divorced,windoed (AOR = 2.964; 95 % CI, 1.482- 5.930) , alcohol use (AOR = 3.994; 95 % CI, 2.091-7.627) and being rural (AOR = .374; 95 % CI, (.184 .761)were associated with injury at p value less-than 0.05. Conclusion: The proportion of injury was high. Being male, age 20 to 45 years, income < 34.2 dollar, being a dailylaborer and alcohol use were factors associated with injury. Hence, appropriate prevention strategies should be strengthened and implemented against intentional injuries. Keywords: Injury, Emergency, Accident, Ethiopia